Journal of Marine Biology and Aquaculture

Invertebrates, in contrast of vertebrate animals, have no acquired immunity, therefore for protection against intussusceptions of foreign agents they use innate immunity system[1]. The part of ancient protective system forming the basis of nonspecific immunity of invertebrates, has served as the precursor of the complicated immunity of vertebrate animals[2]. The antimicrobial function of the innate immunity is realized by using specific “recognition” proteins known as pattern recognition proteins (PRPs) that bind to specific molecules on the surface of pathogens also been called as pathogen-associated molecular patterns (PAMPs) to activate the entire immune system[1]. In Gram-negative bacteria, one of the PAMP compounds is the lipopolysaccharide (LPS). A LPS molecule has an amphiphilic nature and consists of three parts: lipid A, core oligosaccharide, and the O-polysaccharide chain. Proteins that “recognize” LPSs are called LPS-binding proteins (LBP) which are capable interact with both lipid and the carbohydrate moieties of the LPS molecule[3,4]. 1G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far East Branch of Russian Academy of Sciences, Vladivostok, Russia 2Far Eastern Federal University, School of Biomedicine, Vladivostok, Russia